State and local officials are investigating the spill of about 40,000 gallons of manure into a tributary of the New River.
The Virginia Department of Health says in a news release that the manure spilled from a holding tank into Eagle Bottom Creek Monday.
The agency says state officials are working with the city of Galax and Carroll, Grayson and Wythe counties to assess the spill's impact.
Health officials are advising residents to avoid contact with both waterways until further notice.
A water conservation notice also has been issued for the town of Fries in Grayson County until Wednesday afternoon.
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