State Police say 33-year-old Nadat Adoullah was driving her van northbound on I-81 near the Bridgewater exit when she crossed the median into the southbound lane.
A tractor-trailer heading south hit her van head-on, sending both vehicles sliding down the hill.
Adoullah was taken to U.V.A. by Aircare and later died.
Witnesses say the driver of the tractor trailer walked away from the accident but was taken to Rockingham Memorial Hospital.