Police say 26-year-old Michael Keys was driving a motor home the wrong way on Interstate 64 Tuesday.
The chase started when Keys's wife called 911 from a gas station in Augusta County and said her husband shot at her.
He left in their 30-foot long RV, with a seven-year-old boy.
Police say the RV driver tried to run over a state trooper after police deflated his tires.
Keys was arrested by Albermarle police.