For Strasburg (1-0), this marked the start of what should be his first full season in the majors, with zero pitch or inning limits. The All-Star ace was dominant against a trade-depleted Marlins lineup that features Giancarlo Stanton and little else.
The right-hander went seven innings, matching his career high, and allowed three hits.
Reigning NL Rookie of the Year Harper, a 20-year-old outfielder, hit solo shots over the out-of-town scoreboard in right-center field off Ricky Nolasco (0-1) in the first and fourth innings.
New closer Rafael Soriano got the save.